[JACS] 我室徐海超教授发表论文:Electrochemical Difluoromethylarylation of Alkynes

2018年02月09日

我室徐海超 JACS 教授发表论文:Electrochemical Difluoromethylarylation of Alkynes

文章链接:https://pubs.acs.org/doi/10.1021/jacs.8b00391

摘要:

An unprecedented radical difluoromethylarylation reaction of alkynes has been developed by discovering a new difluoromethylation reagent, CF2HSO2NHNHBoc. This air-stable and solid reagent can be prepared in one step from commercially available reagents CF2HSO2Cl and NH2NHBoc. The CF2H radical, generated through ferrocene-mediated electrochemical oxidation of CF2HSO2NHNHBoc, participates in an unexplored alkyne addition reaction followed by a challenging 7-membered ring-forming homolytic aromatic substitution step to afford fluorinated dibenzazepines.